Amikacin

Generic Name (active ingredient): Amikacin
Brand Name: Amikin

Amikacin is a prescription medication that belongs to a group of aminoglycoside antibiotics. Amikacin is used to treat a wide variety of infections caused by sensitive bacteria.

How does the medication work?
Amikacin is half-synthetic broad spectrum aminoglycoside antibiotic. Amikacin works bactericidally by binding to 30S ribosome subunits, prevents the formation of complex of transfer RNA and informational RNA, blocks protein synthesis and destroys bacterial cytoplasmic membranes. Amikacin is highly effective against aerobic gram-negative microorganisms and some gram-positive microorganisms. Amikacin is moderately active against Streptococcus spp., it does not act on anaerobic bacteria.

Why is Amikacin prescribed?
Amikacin is prescribed for the treatment of infections caused by sensitive gram-negative microorganisms (resistant to gentamicin, sizomicin, kanamycin) or certain gram-positive and gram-negative microorganisms:

  • Infections of the respiratory system
  • Sepsis
  • Septic endocarditis
  • CNS infections
  • Infections of the abdominal cavity
  • Urogenital infections
  • Skin and soft tissue infection
  • Infections of the bile passages
  • Wound infections
  • Post-operative infections

What should I know before taking Amikacin?
Do not use this medication if you are allergic to Amikacin or to any other medicines such as:
- Gentamycin, Tombramycin, Kanamycin and other aminoglycoside antibiotics

Do not take Amikacin if any of the below conditions apply to you:

  • Cochlear neuritis
  • Hepatic failure
  • Renal failure with uremia
  • Pregnancy
  • Breastfeeding

If you are pregnant, plan to become pregnant, or breastfeed, you should take Amikacin only under a strict control of your doctor. Amikacin belongs to a pregnancy category D meaning that is may cause significant damage to the fetus in pregnant women.

Before taking Amikacin, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Myasthenia
  • Parkinson's disease
  • Botulism
  • Dehydration
  • Kidney diseases
  • Children
  • Elderly age

How to take Amikacin:
Amikacin is available in the forms of injectable solution. Amikacin is injected in the form of intramuscular or intravenous injections. Dosage of Amikacin is prescribed individually by physician.

Take the entire amount of Amikacin prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return. If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Amikacin?
Amikacin may cause the following side effects:

  • Digestive system: nausea, vomiting, abnormal liver function (increased activity of "liver" transaminases, hyperbilirubinemia).
  • Hemopoietic system: anemia, leukopenia, granulocytopenia, thrombocytopenia.
  • Central nervous system and peripheral nervous system: headache, drowsiness, neurotoxicity (muscle twitching, feeling of numbness, tingling, seizures), violation of neuromuscular transmission (respiratory arrest).
  • Sense organs: ototoxicity (hearing loss, vestibular and labyrinthine disorders, irreversible deafness), the toxic effect on the vestibular apparatus (discoordination movements, dizziness, nausea, vomiting).
  • Urinary system: renal toxicity - renal dysfunction (oliguria, proteinuria, microhematuria).
  • Allergic reactions: skin rash, itching, skin flushing, fever, Quincke's edema
  • Local reactions: pain at the injection site, dermatitis, phlebitis

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required. If you overdose Amikacin, seek immediate medical attention. Overdose symptoms include:

Which are Amikacin overdose symptoms?
Toxic reactions: hearing loss, ataxia, drowsiness, urination disorders, thirst, decreased appetite, nausea, vomiting, stinging in the ears, shortness of breath. In case of overdose seek immediate medical attention.

Which other medicines may affect Amikacin?
Amikacin may interact with the following groups of drugs:

  • Other antibiotics (beta-lactams, cephalosporins, macrolides and others)
  • NSAID's
  • Diuretics
  • Myorelaxants drugs
  • Vitamins
  • Blood thinners
  • Potassium chloride

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Amikacin, let your doctor know what other medicines, including OTC, you currently take.

How should I store Amikacin?
You should store the medication at dry and protected from light place out of reach of children

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