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Aztreonam

Generic Name (active ingredient): Aztreonam
Brand Name: Azactam, Cayston

Aztreonam is monobactam antibiotic that is used to treat infections caused by sensitive to the medication microorganisms: pyelitis, pyelonephritis, pneumonia, meningitis, sepsis. It is active against anaerobic gram-negative microorganisms.

How does the medication work?
Aztreonam is bactericidal monobactam antibiotic that exerts bactericidal action against anaerobic gram-negative microorganisms. Bactericidal action is associated with inhibiting the formation of bacterial cell wall. Aztreonam is resistant to β-lactamases produced by aerobic gram-negative flora and is inactivated by β-lactamases produced by staphylococci, bacteroides, extended spectrum beta lactamases. Aztreonam does not act on acinetobacter, S.maltophilia, B.cepacia, gram-positive cocci and anaerobes.

When Aztreonam is prescribed?

  • Lower respiratory tract infections (pneumonia)
  • Intra-abdominal infections
  • Infections of the pelvic organs
  • Urogenital infections
  • Skin and soft tissue infections
  • Bone and joints infections
  • Sepsis

Aztreonam solution for inhalation is used to improve respiratory symptoms in cystic fibrosis with Pseudomonas aeruginosa.

Taking into consideration that Aztreonam is a narrow spectrum antibiotic, it is usually prescribed in combination with (oxacillin, cephalosporins, lincosamides, vancomycin, metronidazole).

What should I know before taking Aztreonam?
Do not use this medication if you are allergic to Aztreonam or to any other medicines such as:

  • Other monobactams
  • Penicillin beta-lactam antibiotics
  • Cephalosporin beta-lactam antibiotics

Do not take Aztreonam if any of the below conditions apply to you:

  • Severe liver diseases (hepatic failure, hepatitis)
  • Severe kidney diseases (nephritis, pyelonephritis, glomerulonephritis)
  • Severe cardiovascular diseases

Before taking Aztreonam, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Liver and kidney diseases in anamnesis

If you are pregnant, plan to become pregnant, or breastfeed, you should take Aztreonam only under a strict control of your doctor. Aztreonam belongs to a pregnancy category B meaning that safety of the medication in pregnant women has not been studied. Talk to your doctor about benefits and risk of taking Aztreonam medication during pregnancy.

How to take Aztreonam:
Aztreonam is available in the forms of injections and solution for inhalation. Aztreonam injections are made in the form of intravenous or intramuscular injections. Solution for inhalation should be administered immediately after reconstitution using appropriate nebulizer system.
Dosage of Aztreonam is prescribed individually by physician.

Take the entire amount of Aztreonam prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Aztreonam?
The most common Aztreonam side effects include:
Gastrointestinal tract: stomach pain, nausea, vomiting, diarrhea
Liver: jaundice, hepatitis
CNS: headache, drowsiness, confusion, insomnia
Allergic reactions: skin rash, hives, anaphylactic shock
Local reactions: phlebitis, pain in t he injection site
If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Aztreonam overdose symptoms?
If you overdose Aztreonam, seek immediate medical attention. Overdose symptoms include: diarrhea, vomiting, stomach pain.

Which other medicines may affect Aztreonam?
Aztreonam may interact with the following groups of drugs:

  • Beta-lactam antibiotics
  • Inductors of liver microsomal enzymes
  • Carbapenems

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Aztreonam, let your doctor know what other medicines, including OTC, you currently take.

How should I store Aztreonam?
You should store the medication at dry and protected from light place out of reach of children. Do not store the medication in the bathroom.