Benzilpenicillin

Generic Name (active ingredient): Benzylpenicillin
Brand Name: Penicillin G

Benzylpenicillin is a penicillin bactericidal antibiotic for parenteral use. It is used for the treatment of infections caused by sensitive microorganism. It commonly indicated in the treatment of severe infections of the respiratory system and ENT organs, purulent infections, meningitis, syphilis, bacterial endocarditis

How does the medication work?
Benzylpenicillin is penicillin beta-lactam antibiotics for parenteral applications. It exerts bactericidal action on proliferation penicillin-sensitive microorganisms. Bactericidal effects is associated with disturbing the formation of bacterial cell wall. Benzylpenicillin inhibits the enzyme transpeptidase that is necessary for peptidoglycan synthsis. Peptidoglycan is a main component of bacterial cell wall. Benzylpenicillin is effective against infections caused by gram-positive and gram-negative microorganism such as streptococci A, B, C, G, L and M, pneumococci, staphylococci, gonococci and others. Benzylpenicillin is acid resistant and is inactivated by penicillinase (beta-lactamase).

When Benzylpenicillin is prescribed?
Benzylpenicillin is used to treat infectious diseases caused by susceptible to the medication microorganisms:

  • Septicemia, sepsis;
  • Lobar and focal pneumonia, purulent pleurisy, empyema, pericarditis, mediastinitis, peritonitis;
    meningitis, brain abscess;
  • Sore throat, scarlet fever, otitis media, sinusitis, laryngitis, purulent bronchitis;
  • Wound infection, abscesses of skin and soft tissue, mucous membranes, erysipelas;
  • Arthritis, osteomyelitis;
  • Gonorrhea, cystitis;
  • Diseases caused by spirochete, including syphilis, yaws and a pint; specific infections such as anthrax, infections caused by Clostridium, Listeria, Pasteurella;
  • Fever caused by the bite of rat fuzospirohetoz;
  • Diphtheria prevention
  • Prevention of late complications caused by streptococcal infection: rheumatic fever, bacterial endocarditis, polyarthritis, glomerulonephritis

What should I know before taking Benzylpenicillin?
Do not use this medication if you are allergic to Benzylpenicillin or to any other medicines such as:

  • Amoxicillin, Ampicillin, cephalosporins, procaine, novocaine

Do not take Benzylpenicillin if any of the below conditions apply to you:

  • Severe liver diseases (hepatitis, cirrhosis, hepatic failure)
  • Severe kidney diseases (renal failure, pyelonephritis, glomerulonephritis)
  • Arrhythmia
  • Hyperpotassemia

Before taking Benzylpenicillin, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • liver and kidney diseases in anamnesis

If you are pregnant, plan to become pregnant, or breastfeed, you should take Benzylpenicillin only under a strict control of your doctor. Benzylpenicillin belongs to a pregnancy category B meaning that safety of the medication in pregnant women has not been studied.

How to take B enzylpenicillin:
Benzylpenicillin is available in the forms of injectable solution indicated intravenously and intramuscularly. Dosage of Benzylpenicillin is prescribed individually by physician.

Take the entire amount of Benzylpenicillin prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Benzylpenicillin?
Benzylpenicillin may cause the following side effects:

  • Gastrointestinal tract: nausea, diarrhea, stomach pain, stomatitis, glossitis
  • Allergic reactions: anaphylactic shock, urticaria, fever, joint pain, angioedema, erythema multiforme, exfoliative dermatitis
  • Hemopoietic system: hemolytic anemia, leukopenia, thrombocytopenia
  • Cardiovascular system: arrhythmia, heart attacks, hyperpotassemia
  • Urogenital system: renal failure, anuria

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are B enzylpenicillin overdose symptoms?
If you overdose Benzylpenicillin, seek immediate medical attention. Overdose symptoms include: fever, allergic reactions, diarrhea, vomiting, changes in blood cells counts

Which other medicines may affect Benzylpenicillin?
Benzylpenicillin may interact with the following groups of drugs:

  • NSAID's
  • Uricosuric drugs
  • Other beta-lactam antibiotics
  • Aminoglycosides
  • Anti-arrhythmic medications

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Benzylpenicillin, let your doctor know what other medicines, including OTC, you currently take.

How should I store Benzylpenicillin?
You should store the medication at dry and protected from light our of reach of children. Do not store the medication in the bathroom.

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