Generic Name (active ingredient): Cefepime
Brand Name: Maxipime

Cefipime is a IV generation cephalosporin antibiotic for parenteral use. It exerts bactericidal action against a wide variety of microorganisms including gram-positive and gram-negative aerobic bacteria, several anaerobic microorganisms. It is used to treat infections caused by susceptible to cefepime microorganisms.

How does the medication work?
Cefepine possesses a broad spectrum of antibacterial activity against gram-positive and gram-negative microorganisms, including some strains resistant to aminoglycosides and 3rd generation cephalosporin antibiotics. Cefepime is highly resistant to hydrolysis of beta-lactamases. Bactericidal effect is associated with inhibiting the activity of transpeptidase that cross-links peptiglycan chains. Peptidoglycan is a main component of bacterial cell wall. Suppressing peptidoglycan synthesis leads to lysis of microorganisms.

When Cefepime is prescribed?
Cefepime is used to treat infectious diseases caused by sensitivity to the medication microorganisms:

  • Infection of the upper respiratory system including bronchitis
  • Complicated and uncomplicated urinary tract infections (pyelonephritis)
  • Skin and soft tissue infections
  • Intraabdominal infections
  • Gynecological infections
  • Sepsis
  • Empiric treatment in febrile neutropenia

Cefepime is not used to treat infections caused by viruses and fungi

What should I know before taking Cefepime?
Do not use this medication if you are allergic to Cefepime or to any other medicines such as:

  • Beta-lactam penicillin and cephalosporin antibiotics

Do not take Cefepime if any of the below conditions apply to you:

  • Severe liver diseases or kidney diseases (renal impairment)

Before taking Cefepime, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Pseudo-membranous colitis associated with cephalosporins use
  • Pediatric use
  • Geriatric use

Prolonged use of Cefepime may result in overgrowth of non-susceptible microorganisms

If you are pregnant, plan to become pregnant, or breastfeed, you should take Cefepime only under a strict control of your doctor. Cefepime belongs to a pregnancy category B meaning that safety of preparation in pregnant women has not been studied. Talk your doctor about benefits and risk of taking Cefepime during pregnancy.

How to take Cefepime:
Cefepime is available in the form of injectable solution. Cefipime is injected intravenously and intramuscularly deeply. Dosage of Cefepime is prescribed individually by physician.

Take the entire amount of Cefepime prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Cefepime?
Cefepime may cause the following side effects:

  • Hypersensitivity: itching, skin rash, fever
  • Gastrointestinal system: diarrhea, nausea, vomiting, constipation, stomach pain, dyspepsia
  • Cardiovascular system: chest pain, tachycardia
  • Respiratory system: cough, sore throat, shortness of breath
  • CNS: headache, dizziness, insomnia, paresthesia, anxiety, confusion
  • Other: asthenia, hyperhidrosis, vaginitis, peripheral edemas, back pain

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Cefepime overdose symptoms?
If you overdose Cefepime, seek immediate medical attention. Overdose symptoms include: encephalopathy, myoclonus, seizures, and neuromuscular excitability.

Which other medicines may affect Cefepime?
Cefepime may interact with the following groups of drugs:

  • Clinitest tablets (concomitant application may result in false-positive reaction on glucose)
  • Other beta-lactam antibiotics (penicillins and cephalosporins)
  • Aminoglycosides

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Cefepime, let your doctor know what other medicines, including OTC, you currently take.

How should I store Cefepime?
You should store the medication at dry and protected from light place out of reach of children. Do not store the medication in the bathroom.

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