Ceftriaxone

Generic Name (active ingredient): Ceftriaxone
Brand Name:

Ceftriaxone is a half-syntheric cephalosporin antibiotic for parenteral use. It is used in the treatment of many systemic infections caused by susceptible microorganisms: pneumonia, lung abscess, bronchiectasis, mastoiditis, otitis media, pylonephritis, gonorrhea, sepsis, meningitis, peritonitis, infections in patients with neutropenia and impaired immune system.

How does the medication work?
Ceftriaxone is a third-generation cephalosporin antibiotic for parenteral application. It is characterized by prolonged application. Bactericidal activity is associated with suppressing the synthesis of cellular membranes (bacterial cell wall). In vitro ceftriaxone possesses a broad spectrum of antibacterial activity against gram-negative and gram-positive microorganisms. Ceftriaxone is resistant to the most β-lactamases and acts on many strains resistant aminoglycosides and 2nd generation cephalosporins.

When Ceftriaxone is prescribed?

  • Infections of the respiratory system (acute and chronic bronchitis, pneumonia, lung abscess bronchiectasis, pleural empyema)
  • ENT infections (mastoiditis, otitis media)
  • Renal and urinary tract infections (complicated and uncomplicated, pyelitis, acute and chronic pyelonephritis, cystitis, prostatitis, epididymitis
  • Pelvic organs infections
  • Inflammatory diseases of female genitals
  • Intraabdominal infections including peritonitis, cholangitis, empyema of the gall bladder
  • Gastrointestinal infections: typhoid fever, salmonellosis
  • Sepsis, septicemia, bacterial endocarditis
  • Bacterial meningitis
  • Bone and joints infections
  • Skin and soft tissue infections, infected wounds and burns
  • Children infections
  • Infections prophylaxis before surgical interventions
  • Prophylaxis and treatment of infections in patients with neutropenia, weakened immune system and oncology diseases
  • Lyme disease

What should I know before taking Ceftriaxone?
Do not use this medication if you are allergic to Ceftriaxone or to any other medicines such as:

  • Cefexime, Cephalexin and other penicillin and cephalosporin beta-lactam antibiotics

Do not take Ceftriaxone if any of the below conditions apply to you:

  • Severe diseases of the liver or kidney

Before taking Ceftriaxone, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • History of pseudo-membranous colitis associated with cephalosporins therapy
  • History of hemolytic anemia associated with cephalosporins therapy

Prolonged use may increase the risk of yest infection developing and overgrowth of susceptible strains

If you are pregnant, plan to become pregnant, or breastfeed, you should take Ceftriaxone only under a strict control of your doctor. Ceftriaxone belongs to a pregnancy category B meaning that safety of the medication in pregnant women has not been studied. Talk to your doctor about all risks and benefits of taking Ceftriaxone during pregnancy

How to take Ceftriaxone:
Ceftriaxone is available in the form of intravenous and intramuscular injectable solutions. Dosage of Ceftriaxone is prescribed individually by physician. Do not use diluents containing calcium, such as Ringer's solution or Hartmann's solution, to reconstitute Ceftriaxone vials or to further dilute a reconstituted vial for IV administration because a precipitate can form.

Take the entire amount of Ceftriaxone prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Ceftriaxone?
Ceftriaxone may cause the following side effects:

  • Swelling at injection site
  • Skin rash
  • Diarrhea
  • Increased amount of liver enzymes
  • Hives
  • Itching
  • Wheezing
  • Sore throat
  • Bleeding or bruising

In rare cases Ceftriaxone may cause: nausea, vomiting, headache, yeast infection, dizziness, chills, anemia, thrombocytopenia, sweating, enterocolitis, hematuria

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Ceftriaxone overdose symptoms?
If you overdose Ceftriaxone, seek immediate medical attention. Overdose symptoms include: diarrhea, local reactions. In case of overdose symptomatic treatment should be carried.

Which other medicines may affect Ceftriaxone?
Ceftriaxone may interact with the following groups of drugs:

  • Blood thinners (warfarin)
  • Uricosuric drugs (probenicid, Sulfinpyrazone)
  • Calcium containing products
  • Beta-lactam antibacterial (penicillins and cephalosporins)
  • Other antibacterial medications

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Ceftriaxone, let your doctor know what other medicines, including OTC, you currently take.

How should I store Ceftriaxone?
You should store the medication at dry and protected from light place out of reach of children.

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