Chloroquine

Generic Name (active ingredient): Chloroquine
Brand Name:Delagil

Chloroquine is antimalarial, amebecidal and immunodepressive medication. It is used for the treatment and prophylaxis of malaria, extraenteric amebiasis. It also used in the complex treatment of systemic lupus erythematosus, sclerodermia, rheumatoid arthritis, photodermatosis.

How does the medication work?
Chloroquine possesses amebecidal, immunodepressive and antimalarial action. Action mechanism is associated with suppressing DNA synthesis, affection on certain enzymes and immunological processes. Chloroquine exerts potent anti-malarial action, causes death of asexual erythrocytic forms of all types of plasmodia (Plasmodium vivax, Plasmodium malariae, Plasmodium falciparum). Chloroquine does not act on Plasmodium falciparum and their gametocytes

When Chloroquine is prescribed?

  • Malaria (prevention and treatment of all types)
  • Extraenteric amoebiasis
  • Amebic liver abscess
  • Systemic lupus erythematosus (chronic and subacute forms)
  • Rheumatoid arthritis
  • Scleroderma
  • Photodermatosis

What should I know before taking Chloroquine?
Do not take Chloroquine if any of the below conditions apply to you:

  • Hypersensitivity to any any of the medication ingredients
  • Renal failure
  • Hepatic failure
  • Suppressing of intramedullary hematogenesis
  • Severe arrhythmia
  • Psoriatic arhtritis
  • Neutropenia
  • Purpurinuria
  • Pregnancy
  • Breastfeeding

Before taking Chloroquine, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Diabetes
  • Epilepsy
  • Abnormal heart rhythm
  • Liver diseases in anamnesis
  • Kidney diseases in anamnesis

If you are pregnant, plan to become pregnant, or breastfeed, you should take Chloroquine only under a strict control of your doctor. Chloroquine belongs to a pregnancy category C meaning that it is not sae to use the medication during pregnancy because of a high risk of teratogenic and embryotoxic effect.

How to take Chloroquine:
Chloroquine is available in the forms of tablets which should be taken orally swallowing whole. Dosage of Chloroquine is prescribed individually by physician.

Take the entire amount of Chloroquine prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Chloroquine?
Chloroquine may cause the following side effects:

  • Digestive system: nausea, vomiting, stomachalgia
  • Nervous system: dizziness, headache, sleep disorders, psychosis, seizures
  • Cardiovascular system: damage of cardiac tissue, decrease in blood pressure
  • Senses organs: long-term use-corneal clouding, retinal damage, visual disturbances, ringing in the ears
  • Allergic reaction: dermatitis, photosensitivity
  • Other: myalgia, leukopenia, discoloration of skin and hair.

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Chloroquine overdose symptoms?
If you overdose Chloroquine, seek immediate medical attention. Overdose symptoms include: vomiting, vision changes, seizures, collapse, suppressing of respiration center.

Which other medicines may affect Chloroquine?
Chloroquine may interact with the following groups of drugs:

  • NSAID's (phenylbutazone)
  • Preparations of gold
  • Penicillins
  • Cytostatics
  • Anthelmintics (levamisole)
  • Antacids
  • H2-histamine receptor blockers (cimetidine)
  • Corticosteroids
  • MAO inhibitors
  • Cardiac glycosides

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Chloroquine, let your doctor know what other medicines, including OTC, you currently take.

How should I store Chloroquine?
Chloroquine tablets should be stored at dry and protected from light place out of reach of children. Do not store the medication in the bathroom.

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