Cilastatin

Generic Name (active ingredient): Cilastatin/Imipenem
Brand Name: Primaxin, Tienam, Zienam

Cilastatin/Imipenem is beta-lactam antibiotic, carbapenem. Cilastatin/Imipenem is a potent broad spectrum bactericidal antibiotic active against gram-positive and gram-positive bacteria. It is used in the treatment of nosocomial infections, infections of the abdominal cavity, respiratory system, urogenital system, bone and soft tissue infections. It is recommended for patients with post-operative infections

How does the medication work ?
Cilastatin/Imipenem is carbapenem beta-lactam antibiotic with a broad spectrum of antibacterial activity. It exerts potent bactericidal action. Imipenem is the first representative of a new class of beta-lactam antibiotics - carbapenems. This class of antibiotics is characterized by a broad spectrum of bactericidal activity compared with other beta-lactam antibiotics. Cilastatin is a specific inhibitor of the enzyme - dehydropeptidase. It inhibits the metabolism of imipenem in the kidneys and significantly increases the concentration of unchanged imipenem in the urinary tract. Cilastatin does not have its own antibacterial activity and does not inhibit beta-lactamase bacteria. Cilastatin/Imipenem is a potent inhibitor of the bacterial cell wall synthesis and has a bactericidal action against a wide spectrum of gram-positive and gram-negative pathogenic aerobic and anaerobic microorganisms.

When Cilastatin/Imipenem is prescribed ?

  • Nosocomial infections
  • Intraabdominal infections
  • Infections of the lower respiratory system
  • Gynecological infections
  • Sepsis, septicemia
  • Urinary tract infections
  • Skin and soft tissue infections
  • Infectious endocarditis

The medication is indicated for the treatment of mixed infections caused by susceptible microorganisms. It is actively used as monotherapy in oncological patients with weakened immune system.

What should I know before taking Cilastatin/Imipenem ?
Do not use this medication if you are allergic to Cilastatin/Imipenem or to any other medicines such as:

  • Meropenem and other beta-lactam antibiotics

Do not take Cilastatin/Imipenem if any of the below conditions apply to you:

  • Individual intolerance of any of the medication ingredients
  • Pregnancy
  • Breastfeeding
  • Young age
  • Severe renal failure
  • History of allergic reactions to local amide anesthetics
  • Elderly age (with caution)

Before taking Cilastatin/Imipenem, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • CNS diseases
  • Liver diseases
  • HIV positive patients

If you are pregnant, plan to become pregnant, or breastfeed, you should take Cilastatin/Imipenem only under a strict control of your doctor. Cilastatin/Imipenem belongs to a pregnancy category C meaning that it is unsafe to the medication during pregnancy.

How to take Cilastatin/Imipenem:
Cilastatin/Imipenem is available in the form of intravenous injectable solution. Dosage of Cilastatin/Imipenem is prescribed individually by physician.

Take the entire amount of Cilastatin/Imipenem prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return. If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Cilastatin/Imipenem ?

Cilastatin/Imipenem may cause the following side effects:

  • Local reactions: erythema, pain, infiltrates at the injection site, thrombophlebitis.
  • Allergic reactions: rash, itching, urticaria, erythema multiforme, Stevens-Johnson syndrome, angioedema, toxic epidermal necrolysis (rare), exfoliative dermatitis (rare), fever, anaphylactic reactions.
  • Liver: moderate increase in serum transaminases, bilirubin and / or serum alkaline phosphatase, hepatitis (in rare cases).
  • Urinary system: oliguria/anuria, polyuria, acute renal failure (rare).
  • Central and peripheral nervous system: myoclonia, mental disorders, including hallucinations, confusion or seizures (convulsions) paresthesia.
  • Laboratory parameters, blood system:eosinophilia, leukopenia, neutropenia, including agranulocytosis, thrombocytopenia, thrombocytosis, decrease in hemoglobin levels, lengthening of prothrombin time. Nausea and/or vomiting were observed more frequently in patients with granulocytopenia.
  • Other: candidiasis, partial alopecia.

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Cilastatin/Imipenem overdose symptoms ?
If you overdose Cilastatin/Imipenem, seek immediate medical attention. Overdose symptoms include: ataxia, bradypnea, clonic convulsions.

Which other medicines may affect Cilastatin/Imipenem ?
Cilastatin/Imipenem may interact with the following groups of drugs:

  • Antivirals (gancyclovir)

Injectable solution is incompatible with salts of lactic acid, other parenteral antibiotics

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Cilastatin/Imipenem, let your doctor know what other medicines, including OTC, you currently take.

How should I store Cilastatin/Imipenem?
The medication should be stored at room temperature at dry and protected from light place out of reach of children.

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