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Clindamycin

Generic Name (active ingredient): Clindamycin
Brand Name: Dalacin, Duac, BenzaClin, Clindoxyl

Clindamycin is linconsamide antibiotic that is used in the treatment of infections caused by susceptible microorganisms including infections of the respiratory system, ENT infections, skin and soft tissue, bone and joint infections, gynecological infections, sepsis, endocarditis. It is highly effective against aerobic gram-positive and anaerobic microorganisms. Vaginal pharmaceutical forms are used to treat bacterial vaginosis.

How does the medication work?
Clindamycin possesses antibacterial activity against a wide variety of microorganisms including gram-positive and gram-negative microorganisms. The medication possesses bacteriostatic action
which is associated with binding to 50S subunits of ribosomal membrane and inhibit protein synthesis in microorganism. It is active against Staphylococcus, Streptococcus, Clostridium diphtheriae, Mycoplasma spp., Bacteroides spp and other microorganisms.

When Clindamycin is prescribed?
Parenteral form of Clindamycin are indicated for the treatment of infectious diseases caused by susceptible microorganisms:

  • ENT infections (pharyngitis, tonsillitis, sinusitis, otitis media)
  • Upper and lower respiratory tract infections(pneumonia, including aspiration, lung abscess, empyema, bronchitis)
  • Scarlet fever
  • Diphtheria
  • Urogenital tract infections (chlamydial infections, endometritis, vaginal infections)
  • Infections of the abdominal cavity (peritonitis, abscess)
  • Acute and chronic osteomyelitis
  • Septicemia
  • Bacterial endocarditis
  • Peritonitis prophylaxis and intra-abdominal abscesses
  • Treatment of infections caused by staphylococci and other gram-positive microorganisms that are resistant to penicillins.

Vaginal forms of clindamycin are used to treat bacterial vaginitis
Local gel of Clindamycin is used for acne treatment

What should I know before taking Clindamycin?

Do not use this medication if you are allergic to Clindamycin or to any other medicines such as:

  • Lincomycin and other lincosamide antibiotics

Do not take Clindamycin if any of the below conditions apply to you:

  • Hypersensitivity to any of the medication ingredients
  • Myasthenia
  • Bronchial asthma
  • Ulcerous colitis
  • Pregnancy
  • Breastfeeding
  • Children

Before taking Clindamycin, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Liver or kidney failure
  • Elderly patients

If you are pregnant, plan to become pregnant, or breastfeed, you should take Clindamycin only under a strict control of your doctor. Clindamycin belongs to a pregnancy category B meaning that is probably safe to use the medication during pregnancy. Talk to your doctor about risks and benefits of taking them medication during pregnancy

How to take Clindamycin:
Clindamycin is available in the forms of injectable solution, vaginal cream, vaginal suppositories and others.Dosage of Clindamycin is prescribed individually by physician.

Take the entire amount of Clindamycin prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Clindamycin?
Clindamycin injectable solution may cause the following side effects:

  • Digestive system: dyspepsia (stomach pain, nausea, vomiting, diarrhea), esophagitis, jaundice, liver dysfunction, pseudomembranous colitis, dysbacteriosis, hyperbilirubinemia
  • Locomotor system: disorders of nervomuscular conductibility
  • Hemopoietic system: leukopenia, neutropenia, agranulocytosis, thrombocytopenia
  • Irritation, pain and thrombophlebitis at the injection site
  • In i/v injections: decreased blood pressure, dizziness, weakness
  • Other: superinfection

For topical Clindamycin: dermatological skin reactions

For vaginal forms: vaginal irritation, pain, discharges, candidiasis, vulvovaginitis, vaginal infections, disorders of menstrual cycle, uterine bleedings, endometriosis

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Clindamycin overdose symptoms?
If you overdose Clindamycin, seek immediate medical attention. Overdose symptoms include: iarrhea and heightened side effect symptoms.

Which other medicines may affect Clindamycin?
Clindamycin may interact with the following groups of drugs:

  • Aminoglycosides (rifampicin, streptomycin, gentamycin)
  • Myorelaxants
  • Penicillin antibiotics
  • Barbiturates
  • Calcium gluconate
  • Magnesium sulphate
  • Macrolide antibiotics (erythromycin)
  • Vitamin B containing products
  • Anti diarrheal medications

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Clindamycin, let your doctor know what other medicines, including OTC, you currently take.

How should I store Clindamycin?
Clindamycin injectable solution should be stored at dry and protected from light place out of reach of children. Do not store the medication in the bathroom.