Generic Name (active ingredient): Hydroxymethylquinoxilindioxide
Brand Name: Dioxidine

Dioxidine is a synthetic broad-spectrum antimicrobial drug. It is used only by vital indication for the treatment of severe anaerobic or mixed aerobic-anaerobic infections caused by multiresistant strains in case of ineffectiveness or intolerance of other antimicrobial drugs.

How does the medication work?
Dioxidine has a bactericidal effect, the mechanism of which is not fully studied. Activity of dioxidine grows under anaerobic conditions due to the induction of oxygen reactive types formation. It is effective against staphylococci (including some MRSA), streptococci, meningococci, gram-negative bacteria (E. coli, Proteus spp., K.pneumoniae, S.marcescens, P.aeruginosa, Shigella spp., Salmonella spp., P.multocida, M . tuberculosis).
Many anaerobes such as Clostridium spp., Bacteroides spp. (Including B.fragilis), P.acnes, Lactobacterium spp., Bifidobacterium spp., Veilonella spp., Peptostreptococcus spp., P.niger, as well as actinomycetes are sensitive to Dioxidine.
The drug remains active against strains resistant to other antimicrobials. Cross-resistance between Dioxidine and other antimicrobial drugs is not known.

When Dioxidine is prescribed?
Severe forms of purulent bacterial infections:

  • Infections of lower respiratory tract (purulent pleurisy, empyema, lung abscess)
  • Intra-abdominal infections
  • Infections of skin, soft tissues, bones and joints (abscess, phlegmon, suppurative post-traumatic, post-surgical and burn wounds)
  • Central nervous system infections (brain abscess, secondary purulent meningitis)

Dioxidine is used as IV infusion only in hospitals as a reserve drug in severe infections or ineffectiveness / intolerance to other antimicrobial drugs. It is used topically and in the cavity in the form of solution or ointment in various forms of purulent infection in the surgical (neurosurgery), urological and dental practice.

What should I know before taking Dioxidine?
Do not use this medication if you are allergic to Dioxidine.

Do not take Dioxidine if any of the below conditions apply to you:

  • Insufficiency of the adrenal cortex
  • Pediatric patients

If you are pregnant, plan to become pregnant, or breastfeed, you should not take Dioxidine. Dioxidine belongs to a pregnancy category D meaning that it can be harmful to the unborn baby. Dioxidine passes into the breast milk, therefore breastfeeding should be stopped during the therapy with this medication.

How to take Dioxidine:
Dioxidine is available in the forms of aerosol for external use, ointment for external use, solution for intravenous use and local application, solution for intracavitary and external use

Dosage of Dioxidine is prescribed individually by physician.

Take the entire amount of Dioxidine prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Dioxidine?
Dioxidine may cause the following side effects:

  • Gastrointestinal tract: abdominal pain, nausea, vomiting, diarrhea
  • Nervous system: headache, calf muscles cramps
  • Reaction to IV introduction: chills, fever
  • Allergic reactions: rash, urticaria, anaphylactic shock
  • Adrenal cortex: an overdose may cause dystrophy, destruction, development of acute adrenal insufficiency

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Dioxidine overdose symptoms?
If you overdose Dioxidine, seek immediate medical attention. Overdose symptoms include side effects associated with the violation of the synthesis of glucocorticoids (adrenal toxicity), which requires the immediate discontinuation of the drug and appropriate hormone replacement therapy.

Which other medicines may affect Dioxidine?
If necessary Dioxidine is used concurrently with antihistamines or calcium supplements (in case of hypersensitivity to the medicines).
For a complete list of possible interactions ask your doctor or pharmacist. Before taking Dioxidine, let your doctor know what other medicines, including OTC, you currently take.

How should I store Dioxidine?
Store the medicine in a dry, dark place at temperature not above 20 ° C. Keep it away from fire.

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