Doxycycline

Generic Name (active ingredient): Doxycycline
Brand Name: Unidox,Vibramycin, Monodox, Microdox, Periostat

Doxycyclin is tetracyclin antibitions that is used to treat infectious diseases caused by sensitive to the medication microorganisms: respiratory and gastrointestinal infections, purulent skin and soft tissue infections, urogenital infections, sexually transmitted infections.

How does the medication work?
Doxycycline is a broad spectrum tetracyclin antibiotic effective against a wide variety of microorganisms including gram-positive and gram-negative bacteria, also Rickettsia spp., Treponema spp. and Mycoplasma spp. Chlamydia spp. Doxycycline exerts bacteriostatic action associated with interfering with the connection of aminoacyl tRNA with 30S ribosome subunits. Doxycycline suppresses proteins synthesis on ribosomal level. Antibacterial spectrum is close to tetracycline.

When Doxycycline is prescribed?
Doxycycline is prescribed for the treatment of:

  • Respiratory tract infections (including sore throat, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, empyema)
  • ENT infections (including otitis media, sinusitis, tonsillitis)
  • Infection of the urogenital system (cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, endometritis, and endocervicitis salpingoophoritis)
  • Sexually transmitted infections (urogenital chlamydia, syphilis patients with intolerance to penicillins, uncomplicated gonorrhea / as an alternative therapy / granuloma inguinale, lymphogranuloma venereum);
  • Gastrointestinal infections (including cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery)
  • Infections of skin and soft tissue (wound infections associated with insect bites ), severe acne
  • Other diseases (yaws, legionellosis, Chlamydia various localization including prostatitis and proctitis, rickettsiosis, Q fever, Rocky Mountain spotted fever, Lyme disease, erythema migrans, tularemia, plague, actinomycosis, malaria, leptospirosis, psittacosis, ornithosis, anthrax including pulmonary, bartonellosis, whooping cough, brucellosis);
  • Infectious diseases of the eye, in a combination therapy - trachoma;
  • Osteomyelitis
  • Sepsis
  • Subacute bacterial endocarditis
  • Peritonitis

What should I know before taking Doxycycline?
Do not use this medication if you are allergic to Doxycycline or to any other medicines such as:

  • Tetracycline and other antibiotics from tetracycline group

Do not take Doxycycline if any of the below conditions apply to you:

  • Severe liver failure
  • Porphyria
  • Leukopenia
  • Children under 9 years of age
  • Systemic lupus erythematosus
  • Severe hepatic failure

Before taking Doxycycline, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Liver diseases in anamnesis
  • Kidney diseases in anamnesis

If you are pregnant, plan to become pregnant, or breastfeed, you should take Doxycycline only under a strict control of your doctor. Doxycycline belongs to a pregnancy category D meaning that that Doxycycline may cause damages to the fetus in pregnant women.

How to take Doxycycline:
Doxycycline is available in the forms of capsule, tablet, syrup, oral suspension, gel, or injection. Oral forms should be taken with a plenty of water. It is recommended to take the medication with food. Dosage of Doxycycline is prescribed individually by physician.

Take the entire amount of Doxycycline prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Doxycycline?
Doxycycline may cause the following side effects:

  • Nausea
  • Diarrhea
  • Vomiting
  • Heartburn
  • Decreased appetite
  • Increased photosensitivity

Less common Doxycycline side effects include: watery diarrhea, bloody stool, headache, skin rash, joint pain, fever blurred vision
In rare cases Doxycycline may cause: liver damage, vision changes, hypertension, ulcers of the esophagus, hemolytic anemia, thrombocytopenia, enterocolitis, yeast infection.

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Doxycycline overdose symptoms?
If you overdose Doxycycline, seek immediate medical attention. Overdose symptoms include:

Which other medicines may affect Doxycycline?
Doxycycline may interact with the following groups of drugs:

  • Antacids
  • Barbiturates
  • Bile-acid sequestrant cholesterol medications
  • Birth control pills
  • Epilepsy treatment (carbamazepine, phenytoin)
  • HIV treatment
  • Oral typhoid vaccine
  • Penicillins
  • Retinoids
  • Blood thinners (warfarin)
  • μ-opioid agonist (fentanyl)
  • aldosterone antagonis

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Doxycycline, let your doctor know what other medicines, including OTC, you currently take.

How should I store Doxycycline?
You should store the medication at dry and protected from light place out of reach of children.

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