Furazolidone

Generic Name (active ingredient): Furazolidone
Brand Name: Furoxone

Furazolidone is antibacterial and antiprotozoal medication that belongs to a group of medicines called nitrofurans. Furazolidone is used to treat infectious diseases caused by susceptible microorganisms: dysentery, paratyphoid fever, giardiasis, food intoxications, trichomoniasis, infectious wounds and burns, chronic alcoholism

How does the medication work?
Furazolidone belongs to a group of antibacterial and antiprotozoal medications called nitrofurants. Action mechanism is associated with inhibiting the processes of cellular respiration and other biochemical processes in the bacterial cell leading to deformation of bacterial cell wall and lysis of the microorganisms. Furazolidone activates immune system by enhancing the process of phagocytosis.
Furazolidone is active against gram-positive and gram-negative bacteria. It also inhibits the activity of MAO (monoamino oxydase) and increases sensibilization of the organism to ethanol. Depending on concentration Furazolidone exerts bacteriostatic or bactericidal effect.

When Furazolidone is prescribed?
Furazolidone is used to treat infectious diseases caused by sensitive to the medication microorganisms:

  • Dysentery
  • Paratyphoid fever
  • Giardiasis
  • Food intoxications
  • Trichomoniasis
  • Infectious wounds and burns

Furazolidone is also sometimes used to treat chronic alcoholism

What should I know before taking Furazolidone?
Do not use this medication if you are allergic to Furazolidone or to any other medicines such as:

  • Nitrofurantoin, Nifurantel, Nifurtimox and other drugs from nitrofurans group

Do not take Furazolidone if any of the below conditions apply to you:

  • Renal failure
  • Deficiency of G6PD
  • Children and adolescents under 3 years of age
  • Severe diseases of the nervous system
  • Concomitant application with alcohol and certain other medications (MAO inhibitors)
  • Breastfeeding

Before taking Furazolidone, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Kidney dysfunction
  • Liver dysfunction

If you are pregnant, plan to become pregnant, or breastfeed, you should take Furazolidone only under a strict control of your doctor. Furazolidone belongs to a pregnancy category B meaning that there are no known how Furazolide affects fetus. Talk to your doctor about risks and benefits of taking the medication during pregnancy.

How to take Furazolidone:
Furazolidone is available in the forms of tablets. Furazolide tablets should be taken orally (by mouth).
Dosage of Furazolidone is prescribed individually by physician.

Take the entire amount of Furazolidone prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Furazolidone?
Furazolidone may cause the following side effects:

  • Digestive system: nausea, vomiting, diarrhea.
  • Liver: increasing the activity of lover transaminase, cholestasis, hepatitis
  • Allergic reactions: skin rash, muscle pain, joint pain, in rare cases-anaphylactic shock
  • Respiratory system; bronchospasm, cough, chest pain
  • Nervous system: dizziness, headache, general weakness, drowsiness, peripheral polyneuropathy.
  • Hemopoietic system: leukopenia, megaloblastic and hemolytic anemia

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Furazolidone overdose symptoms?
If you overdose Furazolidone, seek immediate medical attention. Overdose symptoms include: acute toxic hepatitis, neurotoxic reactions, bleedings of unknown origin. In case of overdose symptomatic treatment should be carried.

Which other medicines may affect Furazolidone?
Furazolidone may interact with the following groups of drugs:

  • Quinolone antibiotics
  • Chloramphenicols
  • Alcohol
  • MAO inhibitors
  • Tricyclic antidepressants
  • Foods containing thyramine
  • Sympathomimetics

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Furazolidone, let your doctor know what other medicines, including OTC, you currently take.

How should I store Furazolidone?
You should store furazolide tablets at dry and protected from light place out of reach of children.
Do not store the medication in the bathroom.

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