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Josamycin

Generic Name (active ingredient): Josamycin
Brand Name: Wilprafen

Josamycin is a macrolide antibiotic that is used for the treatment of bacterial infections caused by susceptible microorganisms: ENT and respiratory infections, stomatological and urogenital infections.

How does the medication work?
Josamycin is bacteriostatic macrolide antibiotic that is produced by treptomyces narbonensis var. Josamyceticus. Bacteriostatic action of Josamycin is associated with inhibiting synthesis of proteins in the microbial cell. Josamycin penetrates bacterial cell, bind to 50S ribosomal subunits and thus prevents the fixation of tRNA and blocks translocation of peptides from A- and P-centers.

When Josamycin is prescribed?

Infections of the upper respiratory tract and ENT infections:

  • Pharyngitis, otitis media, sinusitis, laryngitis, tonsillitis and paratonsilitis, diphtheria and scarlet fever in the case of hypersensitivity to penicillin.
  • Lower respiratory tract infections: Acute bronchitis, bronchopneumonia, pneumonia (including atypical form), bronchiectasis, whooping cough, ornithosis.
  • Dental infections: ingivitis and periodontal disease, periodontitis.
  • Infections of skin and soft tissues: pyoderma, furunculosis, wound infection, anthrax, erysipelas, acne, lymphangitis, lymphadenitis, lymphogranuloma venereum.
  • Infections of the urogenital system: Prostatitis, urethritis, gonorrhea, syphilis (if you are sensitive to penicillin), chlamydia infections, mycoplasma and mixed infections (chlamydia, mycoplasmosis, ureaplasmosis).

What should I know before taking Josamycin?
Do not use this medication if you are allergic to Josamycin or to any other medicines such as:

  • Roxithromycin, Erythromycin and other macrolide antibiotics

Do not take Josamycin if any of the below conditions apply to you:

  • Hypersensitivity to any of the medication ingredients
  • Pregnancy
  • Severe liver diseases
  • Severe kidney diseases

Before taking Josamycin, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Liver and kidney diseases in anamnesis

If you are pregnant, plan to become pregnant, or breastfeed, you should take Josamycin only under a strict control of your doctor. Josamycin belongs to a pregnancy category B meaning that the safety of the medication was not studied in pregnant women.

How to take Josamycin:
Josamycin is available in the forms of tablets which should be taken orally swallowing whole. Josamycin is also available in the form of soluble tablets.
Dosage of Josamycin is prescribed individually by physician.

Take the entire amount of Josamycin prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Josamycin?
Josamycin may cause the following side effects:

  • Gastrointestinal tract: decreased appetite, nausea, vomiting, heartburn, diarrhea, dysbacteriosis.
  • Liver and bile passages: increased activity of liver enzymes, disorders of urine outflow and jaundice
  • Sense organs: loss of hearing, tinnitus
  • Allergic reactions: hives, angioedema, redness

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Josamycin overdose symptoms?
If you overdose Josamycin, seek immediate medical attention. Overdose symptoms include: nausea, vomiting, diarrhea, headache, dizziness.

Which other medicines may affect Josamycin?
Josamycin may interact with the following groups of drugs:

  • Bactericidal and other bacteriostatic antibiotics
  • Xantines
  • Antihistamines
  • Immunosuppressors (cyclosporine)
  • Cardiac glycosides (digoxin)
  • Hormonal contraceptives

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Josamycin, let your doctor know what other medicines, including OTC, you currently take.

How should I store Josamycin?
You should store the medication at dry and protected from light place out of reach of children. Do not store the medication in the bathroom.