Kanamycin

Generic Name (active ingredient): Kanamycin
Brand Name: Kanamicin

Kanamycin is an aminoglycoside antibiotic of broad-spectrum, produced by Streptomyces kanamyceticus. Has bactericidal action.

How does the medication work?
Kanamycin is active against Mycobacterium tuberculosis, Gram-negative bacteria: Escherichia coli, Shigella spp., Salmonella spp., Proteus spp., Enterobacter spp., Klebsiella pneumoniae, Neisseria gonorrhoeae, Neisseria meningitidis; gram-positive cocci: Staphylococcus spp. (including penicillinase-producing strains). Pseudomonas spp., Streptococcus spp. are resistant or little sensitive to Klamicin. Anaerobic bacteria, yeasts, viruses, and most of the simplest are resistant to Klamicin.

When Kanamicin is prescribed?
For parenteral use:

  • infectious-inflammatory diseases caused by microorganisms sensitive to kanamycin
  • tuberculosis (in case of mycobacterial resistance to streptomycin and isoniazid)

For oral administration:

  • intestinal infection caused by sensitive microflora (including dysentery, dysentery bacteriocarrier, bacterial colitis, enterocolitis)
  • preparation for surgery of the digestive tract

For topical use in ophthalmology:

  • conjunctivitis
  • blepharitis
  • keratitis
  • corneal ulcer

What should I know before taking Kanamicin?
Do not use this medication if you are allergic to Kanamicin or to any other medicines such as:

  • aminoglycosides

Do not take Kanamicin if any of the below conditions apply to you:

  • abnormal liver function
  • hearing loss
  • obstruction of the gastrointestinal tract

For parenteral use:

  • severe chronic renal insufficiency with azotemia and uremia
  • neuritis of 8th pair of cranial nerves
  • pregnancy

Before taking Kanamicin, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • myasthenia
  • botulism
  • parkinsonism
  • renal failure
  • elderly patients
  • premature infants
  • newborn babies

Kanamycin is contraindicated in pregnancy. If it is necessary to use of kanamycin in the lactation period, breastfeeding must be stopped. Kanamicin belongs to a pregnancy category D meaning that it may be harmful to the unborn baby.

How to take Kanamicin:
Kanamicin is available in the forms of tablets, concentrate for solution for infusion, powder for solution for intramuscular injection.

Dosage of Kanamicin is prescribed individually by physician.

Take the entire amount of Kanamicin prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return. If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Kanamicin ?
Kanamicin may cause the following side effects:

  • digestive system: nausea, vomiting, diarrhea, abnormal liver function; during long-term treatment - malabsorption syndrome
  • hemopoietic system: anemia, leukopenia, granulocytopenia, thrombocytopenia
  • central nervous system and peripheral nervous system: headache, drowsiness, fatigue, neurotoxicity
  • sensory organs: ototoxicity (ringing in the ears, hearing loss to irreversible deafness), toxic effect on the vestibular apparatus (movements discoordination, dizziness, nausea, vomiting), neuritis of the auditory nerve; in local application - feeling of a foreign body in the eye (3-5 min), lacrimation, edema and hyperemia of the eyelids
  • secretory and urinary system: increase or decrease in the frequency of urination, thirst, renal dysfunction (cylindruria, microhematuria, albuminuria)
  • allergic reactions: skin rash, itching, skin flushing, fever, edema

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Kanamicin overdose symptoms ?
If you overdose Kanamicin, seek immediate medical attention. Overdose symptoms include: toxic reactions (hearing loss, ataxia, dizziness, disorders of urination, thirst, loss of appetite, nausea, vomiting, ringing in the ears, respiratory failure).

Which other medicines may affect Kanamicin ?
Kanamicin may interact with the following groups of drugs:

  • other antibiotics
  • diuretics
  • NSAIDs
  • anesthetics
  • myasthenia treatment
  • drugs that block neuromuscular transmission
  • direct anticoagulants

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Kanamicin, let your doctor know what other medicines, including OTC, you currently take.

How should I store Kanamicin ?
Store this medicine in a dark, dry place at room temperature.

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