Ketoconazole

Generic Name (active ingredient): Ketoconazole
Brand Name: Ketoconazole

Ketoconazole is an antifungal antibiotic. Ketoconazole is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, or skin.

How does the medication work?
Ketokonazole is an antifungal agent active against dermatophytes, yeasts and dimorphic fungi. The drugs fights also staphylococci and streptococci. The mechanism of action is in inhibition of fungi membrane's ergosterol synthesis and the violation of the permeability of the cell wall. The medication is ineffective against Aspergillus, Zygomycetes. It also reduces the formation of androgens.

When Ketoconazole is prescribed?

  • Fungal infections caused by susceptible pathogens: mycosis of the digestive tract, eyes, genital organs, chronic recurrent vaginal candidiasis, dermatomycoses (including the area of facial hair, scalp, hands), onychomycosis, aphthae, folliculitis, trichophytia, systemic fungal infections (blastomycosis, candidiasis, parakoktsidioidoz, koktsidioidoz, cryptococcosis, histoplasmosis, chromomycosis, sporotrichosis, paronychia, fungal sepsis, fungal pneumonia), leishmaniasis (cutaneous and visceral);
  • Chromophytosis, prevention of fungal infections in patients with increased risk of their development;
  • Prostate cancer (in high doses as an auxiliary anti-androgenic therapy), syndrome of Kashin-Beck (endemic osteoarthrosis deformans), hirsutism (drug therapy as 3 or 4 lines).

What should I know before taking Ketoconazole?
Do not use this medication if you are allergic to Ketoconazole or to any other medicines such as:

  • Untifungal agents

Do not take Ketoconazole if any of the below conditions apply to you:

  • Hypersensitivity, pregnancy, lactation.

Before taking Ketoconazole, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Hepatic and / or renal failure, simultaneous reception of potentially hepatotoxic drugs, alcoholism, achlorhydria, hypochlorhydria,
  • Children (up to 2 years) (safety and efficacy not established).

If you are pregnant, plan to become pregnant, or breastfeed, you should take Ketoconazole only under a strict control of your doctor. Ketoconazole belongs to a pregnancy category (C) meaning that there are no well-controlled studies in pregnant women. The drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

How to take Ketoconazole:
Dosage of Ketoconazole is prescribed individually by physician.

Take the entire amount of Ketoconazole prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.

If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Ketoconazole?
Ketoconazole may cause the following side effects:

  • Digestive system: loss of appetite, nausea, vomiting, abdominal pain, constipation or diarrhea, toxic hepatitis (increased activity of "liver" enzymes, hypercreatininemia).
  • Nervous system: headache, dizziness, drowsiness, paresthesia.
  • Genitourinary system: gynecomastia, decreased libido in men, oligospermia, impotence, dysmenorrhea, azoospermia.
  • Blood-forming organs: thrombocytopenia, leukopenia, hemolytic anemia.
  • Allergic reactions: hives, skin rash, fever, rash, photophobia.
  • Other: alopecia.

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Ketoconazole overdose symptoms?
If you overdose <medicine>, seek immediate medical attention. Overdose symptoms include:

Which other medicines may affect Ketoconazole?
Ketoconazole may interact with the following groups of drugs:

  • Ethanol and other hepatotoxic drugs
  • Oral contraceptives with low hormone concentration
  • Antacids and anticholinergic drugs, H2-histamine receptor blockers
  • Untifungals
  • Indirect anticoagulants
  • Immunosuppressants
  • Hypnotic
  • Glucocorticosteroids
  • Antiviral

For a complete list of possible interactions ask your doctor or pharmacist. Before taking <medicine>, let your doctor know what other medicines, including OTC, you currently take.

How should I store Ketoconazole?
Store in the dark place at room temperature, 15 ° - 30 ° C (59 ° - 86 ° F)

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