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The group of lincosamides includes natural antibacterial preparation lincomycin and its half-synthetic analogue clindamycin, possessing a broad spectrum of antibacterial activity. These medications are used for the treatment of infections caused by gram-positive cocci (as second line preparations) and nonspore-forming anaerobic flora. Pathogenic microorganisms easily develop crossed resistance to both preparations.
Lincosamides exert bacteriostatic action associated with inhibiting protein synthesis by ribosomes. In high concentration lincosamides may exert bactericidal action.
Spectrum of activity
Lincosamides are narrow-spectrum antibiotics which act on staphylococci, streptococci, pneumococci, nonspore-forming anaerobic flora - peptostreptococcus, peptococcus, fusobacterium, bacteroides (including B.fragilis), moderately active against toxoplasma, P.falciparum, pneumocystis.
Taking into consideration low spectrum of antibacterial activity, in case of severe infections they should be combined with antibacterial preparations acting on gram-positive flora (aminoglycosides, fluorquinolones).
Lincosamides side effects
Lincosamides drugs interactions
In concomitant application with inhalational analgetics and muscle relaxant drugs lincosamide increase the risk of neuro-muscular blockage leading to muscular weakness, respiratory arrest.
In concomitant application with opioid analgetics there is an increased risk of respiratory suppression and even apnoea.
Calolin decrease the absorption of lincosamides.
It is not recommended to combine lincosamides with chloramphenicol or macrolides because of their antagonism.
Information for patients
Oral forms of lincosamides should be taken by mouth washing down with a glass of water. Lincomycin should be taken one hour before food. It is necessary to follow strictly dosage regimen according to doctors instructions.
Talk to your doctor if the symptoms of infections do not improve within 7-10 days. Do not use absorbing anti-diarrheal drug within 3-4 hours before and after oral application of lincosamides.