Linezolid

Generic Name (active ingredient): Linezolid

Brand Name: Linospan, Zyvox

Linezolid is an antibiotic of oxazolidinones class. Its main value consists in being very effective in the treatment of infections caused by multiresistant gram-positive cocci.

How does the medication work?
Linezolid has predominantly bacteriostatic action due to the protein synthesis violation. For pneumococcus, B.fragilis and C. perfringens, Linezolid has bactericidal effect.
The medicine is active against the vast majority of both aerobic and anaerobic gram-positive microorganisms, including Staphylococcus spp. (including MRSA and MRSE), Enterococcus spp., S.pneumoniae (including ARVs), Streptococcus spp., Nocardia spp., Corynebacterium spp., L.monocytogenes, Clostridium spp., Peptostreptococcus spp.

When Linezolid is prescribed?

  • pneumonia (community-acquired and hospital)
  • infections of the skin and soft tissues
  • enterococcal infections
  • other infections caused by susceptible anaerobic and aerobic gram-positive organisms, including infections accompanied by bacteremia

What should I know before taking Linezolid ?
Do not use this medication if you are allergic to Linezolid or to any other medicines such as:

  • oxazolidinones

Before taking Linezolid, tell your health care provider about any other medicines you take or if you have any of the following conditions:

  • pregnancy
  • breastfeeding
  • risk of bleeding

If you are pregnant, plan to become pregnant, or breastfeed, you should take Linezolid only under a strict control of your doctor. Linezolid belongs to a pregnancy category C meaning that it is possible to use the medication if the expected effect of the therapy outweighs the potential risk to the fetus.
It is not known whether linezolid passes into the breast milk in humans. Caution must be exercised when using linezolid in the period of breastfeeding.

How to take Linezolid:
Linezolid is available in the form of granules for suspension for oral administration, solution for infusions, coated tablets

Dosage of Linezolid is prescribed individually by physician.

Take the entire amount of Linezolid prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Linezolid ?
Linezolid may cause the following side effects:

  • nervous system: headache
  • cardiovascular system and blood (hematopoiesis, hemostasis): hematological parameters deviations (anemia, thrombocytopenia)
  • gastrointestinal tract: abdominal pain (including spastic), bloating, diarrhea, nausea, vomiting, taste perversion, pseudomembranous colitis
  • other: allergic reactions, candidiasis

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Linezolid overdose symptoms?
If you overdose Linezolid, seek immediate medical attention. Overdose symptoms include: nausea, vomiting, diarrhea

Which other medicines may affect Linezolid ?
Linezolid may interact with the following groups of drugs:

  • adrenergic agents
  • antifungal drugs
  • neuroleptics
  • anxiolytics
  • some antibiotics
  • anticonvulsants
  • some antimicrobial drugs

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Linezolid, let your doctor know what other medicines, including OTC, you currently take.

How should I store Linezolid ?
The drug should be stored at temperature below 25 ° C (77 F).

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