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Generic Name (active ingredient): Metronidazole
Brand Name: Flagyl
Metronidazole-is broad spectrum action antibacterial and antiprotozoal medication. Metronidazole is the drug of choice in the treatment of many parasitic diseases in humans caused by protozoa; it is active against vaginal Trichomonas and Giardia intestinal. It is used for the treatment of trichomoniasis, giardiasis, amebiasis, gastric and duodenal ulcer (eradication of Helicobacter pylori), anaerobic infections (peritonitis, abscess, meningitis, empyema, endocarditis). Metronidazole causes disulferam-like reactions.
How does the medication work?
Metronidazole belongs to a group of nitro-5-imidazole and is active mainly against anaerobic microorganisms. Action mechanism is associated interaction of deoxidated 5-nitro group with bacterial DNA and inhibiting synthesis of nucleic acid. This is ultimately fatal for the microorganisms.
Metronidazole suppresses the development of amoebae, Trichomonas as well as some obligate anaerobes: Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia, Peptostreptococcus, Clostridium sp., Bacteroides sp., Prevotella, Fusobacterium, Veilonella.
Some aerobic gram-negative bacteria (Helicobacter, gardnerellas) are sensitive to Metronidazole. Concomitant application with alcohol leads to disulfiram-like reaction.
When Metronidazole is prescribed?
Oral forms of Metronidazole are used in:
What should I know before taking Metronidazole?
Do not use this medication if you are allergic to Metronidazole or to any other medicines such as:
Do not take Metronidazole if any of the below conditions apply to you:
Before taking Metronidazole, tell your health care provider about any other medicines you take or if you have any of the following disorders:
If you are pregnant, plan to become pregnant, or breastfeed, you should take Metronidazole only under a strict control of your doctor. Metronidazole belongs to a pregnancy category B meaning that safety of the medication was not studied in pregnant women. Talk to your doctor about benefits and risk of taking this medication during pregnancy.
How to take Metronidazole:
Metronidazole is available in the form of tablets, vaginal tablets, vaginal gel, solution for infusions, creams, vaginal suppositories. Dosage of Metronidazole is prescribed individually by physician.
Take the entire amount of Metronidazole prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.
What are the side effects of Metronidazole?
Metronidazole may cause the following side effects:
If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.
Which are Metronidazole overdose symptoms?
If you overdose Metronidazole, seek immediate medical attention. Overdose symptoms include: nausea, vomiting, ataxia, in severe cases-peripheral neuropathy and epileptic seizures.
Which other medicines may affect Metronidazole?
Metronidazole may interact with the following groups of drugs:
For a complete list of possible interactions ask your doctor or pharmacist. Before taking Metronidazole, let your doctor know what other medicines, including OTC, you currently take.
How should I store Metronidazole?
Metronidazole should be store at dry and protected from light place at room temperature out of reach of children.