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Monobactams belong to a group of monocyclic β-lactams. Monobactams are obtained from the bacteria Chromobacterium violaceum. Among monobactams only aztreonam is currently used in clinical practice. It possesses a narrow spectrum of antibacterial activity and is used to treat infections caused by gram-negative aerobic flora.
Spectrum of activity
Action mechanism is associated with suppressing the formation of bacterial cell wall. Aztreonam is resistant to many β-lactamases produced by gram-negative flora. It is effective against Enterobacteriaceae and P.aeruginosa resistant to nosocomial strains resistant to cephalosporins, aminoglycosides. It does not act on acynetobacter, S.maltophilia, B.cepacia, gram-positive cocci and anaerobs.
Indications
Monobactams are indicated for the treatment of lower respiratory tract infections, intra-abdominal infections, pelvic organ infections, urogenital infections, skin and soft tissue infections, sepsis. Monobactams are actively used in combination with other preparations for the treatment of mixed infections.
Contraindications:
Monobactams are contraindicated for patients with known reactions of hypersensitivity to monobactams or beta-lactam antibiotics. They should be used with caution in patients with liver and kidney diseases.
Cautions:
Side effects
The most common side effects typical for monobactams include:
Drug interactions:
It is not recommended to combine the medication with carbapenems