Moxifloxacin

Generic Name (active ingredient): Moxifloxacin
Brand Name: Avelox, Vigamox, Moxicin

The preparation is an antibiotic, which belongs to fourth generation synthetic fluoroquinolone antibacterial agents. The preparation exerts its effect against a wide variety of bacterial strains including strains resistant to other types of treatment.

How does the medication work?
Moxifloxacin is a bactericidal drug. The preparation is effective against gram-positive and negative microorganisms, as well as against anaerobic, atypical and acid-resistant bacteria. The preparation is effective against bacterial strains that are resistant to beta-lactam antibiotics as well as to macrolides, strains of staphylococcus resistant to Methicilin and etc. The effects of the drug strongly depend on its concentration in the blood and tissues. The drug does not express cross resistance to penicillins, cephalosporines, aminoglycosides, macrolides or tetracyclines. The overall percentage of resistance development is low. Cross resistance appears between moxifloxacin and other drugs of the same class fluoroquinolones.

In oral administration the preparation is almost completely absorbed. Bioavailability of the preparation reaches 90%. Binding to blood proteins reaches 40%. The preparation is distributed rapidly all over the body. The half-life of the drug is 12 hours. The drug is excreted without transformation or as inactive metabolites. 45% of the drug is excreted with urine and fecal masses.

When Avelox is prescribed?
The preparation is prescribed in treatment of susceptible bacterial infections in adults older then 18 years of age in the following cases:

  • Acute bacterial sinusitis
  • Aggravation of chronic bronchitis caused by a bacterial infection
  • Community-acquired pneumonia
  • Non-complicated skin and soft tissue infections

What should I know before taking Moxifloxacin?
Do not use this medication if you are allergic to Avelox or to any other medicines such as:

  • Other fluoroquinolones
  • Antiarrhythmics

Do not take Moxifloxacin if any of the below conditions apply to you:

  • Hypersensitivity to any components of the pill
  • Age prior to 18 years
  • Arrhythmia
  • CNS disease
  • Epilepsy
  • Expressed liver failure

Before taking Avelox, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Renal impairment
  • Age older then 65 years

If you are pregnant, plan to become pregnant, or breastfeed, you should take Moxifloxacin only under a strict control of your doctor. Avelox belongs to a pregnancy category C meaning that it should only be used during pregnancy is the benefits to the mother outweigh the potential risks to the fetus.

How to take Moxifloxacin:
Avelox is available in the forms of tablets, injectable solution or eye drops. The preparation is administered as intravenous infusions 400mg once a day slowly over a period of 60 minutes. The length of the treatment depends on the indications of the health care provider. The treatment should take place in ambulatory conditions. The infusions should be made by a health care professional. The dosage of the oral forms should be prescribed by your health care provider individually. Take the entire amount of Avelox prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return. If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Moxifloxacin?
Avelox may cause the following side effects:

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Asthenia
  • Weakness
  • Insomnia/somnolence
  • Anxiety
  • Confusion
  • Tremor
  • Vertigo
  • Paresthesia
  • Change of taste
  • Agitation
  • Seizures
  • Depression
  • Hallucinations
  • Emotional lability
  • Tachycardia
  • Hypertension
  • Peripheral edema
  • Leukopenia
  • Thrombocytopenia
  • Anemia
  • Meteorism
  • Dyspepsia
  • Jaundice
  • Vaginal thrush
  • Vaginitis
  • Rash
  • Irritation
  • Allergic reactions
  • Pain syndrome
  • Arthritis
  • Myalgia

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Moxifloxacin overdose symptoms?
If you overdose Avelox, seek immediate medical attention. The immediate treatment of overdose includes: abdominal lavage, adequate hydration, symptomatic therapy.

Which other medicines may affect Moxifloxacin?
Avelox may interact with the following groups of drugs:

  • Corticosteroids
  • Antacids
  • Me + containing drugs
  • Vitamins
  • HIV preparations
  • Nonsteroidal anti-inflammatory drugs
  • Thyroid vaccine
  • QT-prolonging medications
  • ACE inhibitors(quinapril)
  • Blood thinners(warfarin)

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Moxifloxacin, let your doctor know what other medicines, including OTC, you currently take.

How should I store Avelox?
The preparation should be kept away from children at temperatures not exceeding 25C.

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