Norfloxacin

Generic Name (active ingredient): Norfloxacin
Brand Name: Noroxin, Nolicin

Norfloxacin is antibacterial preparation that belongs to a group of medicines called fluroquinolone. It is used for the treatment of infections caused by susceptible microorganisms: cystitis, pyelonephritis, gonorrhea, prostatitis, adnexitis, intestinal infections.

How does the medication work?
Norfloxacin is a broad spectrum fluroquinolone antibiotic that possesses a broad spectrum of antibacterial activity. Action mechanism is associated with suppressing the enzyme DNA-gyrase that provides spiralization and stability of DNA. Norfloxacin possesses a broad spectrum of antibacterial activity. It is highly effective against infections caused by gram-negative microorganisms.

When Norfloxacin is prescribed?
Norfloxacin is used to treat bacterial infections caused by susceptible microorganisms:

  • Acute and chronic infections of the urogenital system (urethritis, cystitis, pyelonephritis)
  • Infections of the genitals (chronic bacterial prostatitis, cervicitis, endomethritis)
  • Uncomplicated gonorrhea
  • Bacterial gastroenteritis (salmonellosis, shigellosis)
  • Sepsis prophylaxis in patients with neutropenia
  • Prophylaxis of traveler's diarrhea

Norfloxacin ear and eye drops are used in:

  • Conjunctivitis (including gonococcal)
  • Keratitis
  • Keratoconjunctivitis
  • Corneal ulcer
  • Blepharitis
  • Trachoma
  • External otitis
  • Acute and chronic otitis media
  • Inner ear infection

What should I know before taking Norfloxacin?
Do not use this medication if you are allergic to Norfloxacin or to any other medicines such as:

  • Ofloxacin, Levofloxacin and other

Do not take Norfloxacin if any of the below conditions apply to you:

  • Hypersensitivity to any of the medication ingredients
  • Deficiency of G6PD
  • Severe liver diseases
  • Severe kidney diseases
  • Patients under 18 years of age
  • Pregnancy
  • Breastfeeding

Before taking Norfloxacin, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Atherosclerosis of the cerebral blood vessels
  • Disorders of cerebral blood circulation
  • Epilepsy
  • Epileptic syndrome
  • Liver diseases
  • Kidney diseases
  • Allergic reactions to acid acetylsalicylic

If you are pregnant, plan to become pregnant, or breastfeed, you should take Norfloxacin only under a strict control of your doctor. Norfloxacin belongs to a pregnancy category C meaning that it is not safe to use the medication during pregnancy because of very high risk of teratogenic effects and embryotoxicity.

How to take Norfloxacin:
Norfloxacin is available in the forms of coated tablets and eye and ear drops. Dosage of Norfloxacin is prescribed individually by physician.

Take the entire amount of Norfloxacin prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Norfloxacin?
Norfloxacin is usually well tolerated and side effects are not common. Norfloxacin may cause the following side effects:

  • Digestive system: nausea, heartburn, anorexia, diarrhea, stomach pain
  • CNS: headache, drowsiness, tiredness, insomnia, hyper irritability, anxiety
  • Urinary tract: interstitial nephritis
  • During the treatment: the increase of transaminases, urea, creatinine, alkaline phosphatase, lactate dehydrogenase.

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Norfloxacin overdose symptoms?
If you overdose Norfloxacin, seek immediate medical attention. Overdose symptoms include: nausea, vomiting, diarrhea, headache, drowsiness, anxiety.

Which other medicines may affect Norfloxacin?
Norfloxacin may interact with the following groups of drugs:

  • Milk and Jogurt (Norfloxain should be taken 2 hours after or before taking milk products)
  • Antacids
  • Preparations of iron, magnesium, calcium, zinc decrease the absorption of norfloxacin
  • Theophylline (xantine) increases the risk of side effects when is taken with norfloxacin
  • Norfloxain enhances the effects of warfarin (blood thinner)
  • Norfloxacin increases blood concentration of cyclosporine in the blood.

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Norfloxacin, let your doctor know what other medicines, including OTC, you currently take.

How should I store Norfloxacin?
You should store the medication at dry and protected from light place out of reach of children.

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