Generic Name (active ingredient): Oseltamivir
Brand Name: Tamiflu

Oseltamivir is an antiviral drug, which is normally prescribed in treatment of flu infections. The preparation belongs to a class of neurominidase inhibitors and has proven to be efficient in treatment of Flu viruses type A and B.

How does the medication work?
The preparation is an antiviral drug. The active ingredient of Tamiflu is a pro-drug which after is metabolized into oseltamivir carboxylat. The active metabolite inhibits viral neurominidase thus preventing the spread of the virus in the respiratory tract to other healthy cells. The registered frequency of resistant strains apparition is 2%.
After administration is nearly completely absorbed from the GI tract. After first pass metabolism 75% of the active prodrug reaches the blood . Protein binding - 3%. Half-life of the drug varies from 1 to 3 hours. The preparation is excreted mostly via kidney route, less then 20% of the drug are eliminated with fecal masses.

When Tamiflu is prescribed?
The preparation is prescribed in treatment and prophylaxis of flu infections in children form 1 year, teenagers and adults.

What should I know before taking Oseltamivir ?
Do not use this medication if you are allergic to Tamiflu or to any other medicines such as:

  • Antivirals of the same class

Do not take Oseltamivir if any of the below conditions apply to you:

  • Hypersensitivity to any components of the drug
  • Renal failure
  • Liver failure
  • Age prior to 1 year

Before taking Tamiflu, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Elderly age
  • Liver or renal disorders
  • Known allergy to any other antiviral drugs

If you are pregnant, plan to become pregnant, or breastfeed, you should take Oseltamivir only under a strict control of your doctor. Tamiflu belongs to the pregnancy category C meaning that the preparation can be used in treatment during pregnancy only in cases when the benefits to the mother outweight the risk to the child.

How to take Oseltamivir:
Tamiflu is available in the forms of capsules.
Dosage of Oseltamivir is prescribed individually by physician.
Take the entire amount of Tamiflu prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Oseltamivir ?
Tamiflu may cause the following side effects:

  • Gastrointestinal tract: nausea, vomiting, diarrhea, abdominal pain
  • CNS: insomnia, dizziness, headache
  • Respiratory system: nasal congestion, coughing, sore throat
  • Weakness, tiredness

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Oseltamivir overdose symptoms ?
If you overdose Tamiflu, seek immediate medical attention. The treatment should be symptomatic, a specific antidote has not been found.

Which other medicines may affect Oseltamivir ?
Tamiflu may interact with the following groups of drugs:

  • Cancer treatment
  • Immunosupressants
  • Oral steroids

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Oseltamivir, let your doctor know what other medicines, including OTC, you currently take.

How should I store Tamiflu?
Tamiflu should be stored in a dry place away from sunlight, at temperatures not exceeding 25°C. The preparation should not be frozen and should be kept away from children.

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