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Oxazolidinones are modern group of antibacterial preparations. Currently only Linezolid is available in clinical practice. It is indicated for the treatment of infections caused by polyresistant gram-positive cocci.
Oxazolidinones exert bacteriostatic action which is associated with inhibiting protein synthesis. Linezolid acts bactericidally against pneumococcus, B.fragilis and C.perfringens. Cross-resistance with other antibacterial preparations is not observed.
Spectrum of activity
Linezolid possesses antibacterial activity against the majority of aerobic and anaerobic gram-positive microorganisms including Staphylococcus spp. (MRSA and MRSE), Enterococcus spp. (including vancomycin resistant strains), S.pneumoniae, Streptococcus spp., Nocardia spp., Corynebacterium spp., L.monocytogenes, Clostridium spp., Peptostreptococcus spp.
Linezolid does not act on the majority of gram-negative microorganisms, however, exerts moderate activity against M.catarrhalis, H.influenzae, Legionella spp., N.gonorrhoeae, B.pertussis, F. meningosepticum, P.multocida as well as some gram-negative strains (Bacteroides spp., Prevotellaspp., F.nucleatum).
Oxazolidinones are used to treat:
Linezolid solution for infusion should not be mixed with ceftriaxone, amphoterecin B, diazepam, erythromycin, co-trimoxazole, phenytoin, pentamidine.
Linezolid is moderate MAO inhibitor, therefore it may enhance vasoconstrictive effects of dopamine, pseudoephedrine, phenyipropanolamine.
Information for patients
Linezolid tablets can be taken with or without food, before, during and after food intake. It is necessary to take the medication exactly as prescribed by your doctor. Consult your doctor if the symptoms of the disease does not improve within 7 days.