Polymixin B

Generic Name (active ingredient): Polymyxin B

Polymyxin B is polypeptide antibiotic that is used to treat bacterial infections caused by sensitive to the medication microorganisms. The medication acts against the majority of gram-negative bacteria.

How does the medication work?
Polymyxin B is polypeptide antibiotic. Action mechanism is associated with blockage of permeable cytoplasmatic bacterial membrane leading to its destruction. Polymyxin B is active against the majority of gram-negative bacteria: scherichia coli, Enterobacter spp., Klebsiella spp., Haemophilus influenzae, Bordetella pertussis, Salmonella spp., Shigella spp., it is especially active against Pseudomonas aeruginosa. Serratia marcescens, Providencia spp., Bacteroides fragilis are resistant to Polymyxin B

When Polymyxin B is prescribed?
The medication is used to treat bacterial infections caused by susceptible microorganisms:

  • Sepsis
  • Meningitis
  • Pneumonia
  • Infections of the urogenital system
  • Bacterial eye infections (locally)
  • Otitis externa (locally)
  • Infectious burns caused by Pseudomonas aeruginosa

What should I know before taking Polymyxin B?
Do not use this medication if you are allergic to Polymyxin B or to any other medicines such as:

  • Polymyxin M and other polypeptide antibiotics

Do not take Polymyxin B if any of the below conditions apply to you:

  • Hypersensitivity to any of the medication ingredients
  • Myasthenia (muscle pain)
  • Botulism
  • Pregnancy
  • Breastfeeding

Before taking Polymyxin B, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Liver diseases in anamnesis
  • Kidney diseases in anamnesis

If you are pregnant, plan to become pregnant, or breastfeed, you should take Polymyxin B only under a strict control of your doctor. Polymyxin B belongs to a pregnancy category C meaning that it is not safe to use the medication during pregnancy because of high risk of teratogenic and embryotoxic effects.

How to take Polymyxin B:
Polymyxin B is available in the forms of injectable solution and in different local forms in combination with other preparations: such as vaginal supplements, ear drops, nasal spray and others.

Dosage of Polymyxin B is prescribed individually by physician.
Take the entire amount of Polymyxin B prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Polymyxin B?
Polymyxin B may cause the following side effects:

  • Urinary system: nephrotoxicity that initially manifests in increased levels of creatinine and urea in the blood. Also the medication may cause severe proteinuria and hematuria
  • Nervous System: paresthesias, vertigo, weakness, peripheral neuropathy, confusion, hearing and mental disorders.
  • Possible neuromuscular blockade with a threat of paralysis of respiratory muscles. The risk factors include renal failure, myasthenia gravis.
  • Hematologic reactions: thrombocytopenia.
  • Metabolic disorders: hypokalemia, hypocalcemia.
  • Local reactions: pain and tissue damage in the injection site
  • Allergic reactions: rash, hives, bronchospasm, hypotension, collapse.
  • Other: curare-like reactions

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Polymyxin B overdose symptoms?
If you overdose Polymyxin B, seek immediate medical attention. Overdose symptoms include:

Which other medicines may affect Polymyxin B?
Polymyxin B may interact with the following groups of drugs:
- For a complete list of possible interactions ask your doctor or pharmacist. Before taking Polymyxin B, let your doctor know what other medicines, including OTC, you currently take.

How should I store Polymyxin B?
Polymyxin B should be stored at dry and protected from light place at room temperature.

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