Polymyxin M

Generic Name (active ingredient): Polymyxin M
Brand Name: Mattacin

The preparation is antibiotic belonging to the class of polymyxines. The preparation is characterized by a narrow spectrum of activity. The preparation is used in treatment of gastrointestinal infections.

How does the medication work?
The preparation is effective in treatment of gram-negative bacteria. In oral administration the preparation is absorbed weakly, due to that fact it is mostly used in treatment of gastrointestinal infections. The drug exerts bactericidal effects through destruction of the cytoplasmic membranes of the bacteria. The preparation is not absorbed in the GI tract and is excreted completely via the fecal route.

When Polymyxin M is prescribed?
The drug is prescribed in treatment of susceptible GI infections:

  • Infectious enterocolitis
  • Dysentery

The local form of the drug is used in treatment of the following susceptible infeciones:

  • Bed sores
  • Infected wounds
  • Necrotic ulcers
  • Purulent otitis

What should I know before taking Polymyxin M?
Do not use this medication if you are allergic to Polymyxin M or to any other medicines such as:

  • Other preparetions belonging to the group of polymyxines

Do not take Polymyxin M if any of the below conditions apply to you:

  • Hypersensitivity to any components of the preparations
  • Renal failure
  • Liver failure

Before taking Polymyxin M, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Pregnancy
  • Lactation period
  • Liver impairment

If you are pregnant, plan to become pregnant, or breastfeed, you should take Polymyxin M only under a strict control of your doctor.

How to take Polymyxin M:
Polymyxin M is available in the forms of tablets, solution and ointment.
Dosage of Polymyxin M is prescribed individually by your physician.
Take the entire amount of Polymyxin M prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Polymyxin M?
Polymyxin M may cause the following side effects:

  • Renal impairment
  • Local allergic reactions
  • Superinfections
  • Rash
  • Irritation

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Polymyxin M overdose symptoms?
If you overdose Polymyxin M, seek immediate medical attention. Overdose symptoms include:

  • Muscle paralysis
  • Renal impairment

The treatment includes administration of atropin with neostigmin, artificial respiration, symptomatic treatment.

Which other medicines may affect Polymyxin M?
Polymyxin M may interact with the following groups of drugs:

  • Myorelaxants
  • Aminoglycosides
  • Other antibiotics

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Polymyxin M, let your doctor know what other medicines, including OTC, you currently take.

How should I store Polymyxin M?
The drug should be kept out of reach of children, away from direct sunlight, at temperatures not exceeding 25C.

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