Generic Name (active ingredient): Proguanil
Brand Name: Paludrine

Proguanil is an antimalarial drug, a biguanide derivative.

How does the medication work?
Proguanil and its active metabolite cycloguanil block dihydrofolate reductase, resulting in disturbed synthesis and conversion of folic acid, which leads to disturbed synthesis of nucleic acids and proteins in the causative organism. Proguanil is a typical blood schizontocidal drug suppressing erythrocytic forms of all types of malaria. However, by its schizontocidal activity Proguanil is inferior to chloroquine. In addition, it stops the reproduction of the malaria parasite, Plasmodium falciparum and Plasmodium vivax in the red blood cells. Proguanil has a marked sporontocidal action, resulting in the mosquito being not able to complete the process of sporogony.

When Proguanil is prescribed?

  • Treatment and prevention of malaria

What should I know before taking Proguanil?
Do not use this medication if you are allergic to Proguanil or to any other medicines such as:

  • biguanides

Before taking Proguanil, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • renal and / or hepatic insufficiency

If you are pregnant, plan to become pregnant, or breastfeed, you should take Proguanil only under a strict control of your doctor.

How to take Proguanil:
Proguanil is available in the form of tablets.

Dosage of Proguanil is prescribed individually by physician.

Take the entire amount of Proguanil prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Proguanil ?
Proguanil may cause the following side effects:

  • gastrointestinal tract: aphthous stomatitis, upset stomach
  • nephrotoxicity - irritation of the kidneys, hematuria

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Proguanil overdose symptoms ?
If you overdose Proguanil, seek immediate medical attention. Overdose symptoms include: bloody urine, abdominal pain, vomiting, painful urination, lower back ache

Which other medicines may affect Proguanil ?
Proguanil may interact with the following groups of drugs:

  • anticoagulants

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Proguanil, let your doctor know what other medicines, including OTC, you currently take.

How should I store Proguanil ?
Store the medicine at room temperature, far from heat, moisture, and direct light. Do not freeze. Keep out of the reach of children.

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