Tetracycline

Generic Name (active ingredient): Tetracycline
Brand Name: Macrocilin, Tetrabact, Tetrebra, Sumycin, Terramycin, Tetracyn, Panmycin

Tetracycline is a bacteriostatic antibiotic from the tetracyclines class. It violates the formation of a complex between the transport RNA and the ribosome, which leads to suppression of protein synthesis.

How does the medication work?
Tetracycline is active against gram-positive microorganisms: Staphylococcus spp. (including Staphylococcus aureus, including penicillinase-producing strains), Streptococcus spp. (including Streptococcus pneumoniae), Listeria spp., Bacillus anthracis, Clostridium spp., Actinomyces israelii; gram-negative microorganisms: Haemophilus influenzae, Haemophilus ducreyi, Bordetella pertussis, the majority of Enterobacteriaceae: Escherichia coli, Enterobacter spp., including Enterobacter aerogenes, Klebsiella spp., Salmonella spp., Shigella spp., Yersinia pestis, Bartonella bacilliformis, Vibrio cholerae, Vibrio fetus, Rickettsia spp., Borrelia burgdorferi, Brucella spp. (in combination with streptomycin), with contraindications to penicillins-Clostridium spp., Neisseria gonorrhoeae, Actinomyces spp.; Tetracycline is also active against causative agents of venereum and groin lymphogranuloma, Treponema spp. Microorganisms resistant to tetracycline: Pseudomonas aeruginosa, Proteus spp., Serratia spp., the majority of strains Bacteroides spp. and fungi, viruses, beta-hemolytic streptococci of group A (including 44% of strains of Streptococcus pyogenes and 74% of strains of Streptococcus faecalis).

When Tetracycline is prescribed?
Infectious diseases caused by susceptible pathogens:

  • pneumonia and respiratory infections caused by Mycoplasma pneumoniae
  • respiratory tract infections caused by Haemophilus influenzae and Klebsiella spp.
  • bacterial infections of urogenital system
  • skin and soft tissue infections
  • ulcerous-necrotic gingivostomatitis
  • conjunctivitis
  • acne
  • actinomycosis
  • intestinal amebiasis
  • anthrax
  • brucellosis, bartonellosis
  • chancroid, cholera
  • chlamydial infections, uncomplicated gonorrhea
  • granuloma inguinale, lymphogranuloma venereum
  • listeriosis, plague, psittacosis, rickettsial pox
  • Rocky Mountain spotted fever, typhus
  • syphilis, trachoma , tularemia, yaws

What should I know before taking Tetracycline?
Do not use this medication if you are allergic to Tetracycline or to any other medicines such as:

  • other tetracycline agents

Do not take Tetracycline if any of the below conditions apply to you:

  • pregnancy
  • breastfeeding
  • children below 8 years of age
  • severe pathology of the liver
  • renal failure

If you are pregnant, plan to become pregnant, or breastfeed, you should take Tetracycline only under a strict control of your doctor. Tetracycline belongs to a pregnancy category D meaning that the use of the drug during pregnancy is not recommended as it passes through placenta and can cause severe developmental disorders of bone tissue in the unborn baby. Tetracycline penetrates into breast milk and may adversely affect the development of bones and teeth of the baby. During the treatment with Tetracycline, a nursing mother must discontinue breastfeeding.

How to take Tetracycline:
Tetracycline is available in the forms of coated tablets, capsules, ointment.

Dosage of Tetracycline is prescribed individually by physician.

Take the entire amount of Tetracycline prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Tetracycline ?
Tetracycline may cause the following side effects:

  • digestive system: loss of appetite, vomiting, diarrhea, nausea, glossitis, esophagitis, gastritis, gastric ulcer, duodenal ulcer, hypertrophy of tongue papillae, dysphagia, hepatotoxic effects, pancreatitis, intestinal dysbiosis
  • nervous system: increased intracranial pressure, vertigo or instability
  • hematopoiesis: hemolytic anemia, thrombocytopenia, neutropenia
  • urinary system: azotemia, hypercreatininemia
  • allergic and immunopathological reactions: maculopapular rash, skin flushing, angioedema, anaphylactoid reactions, drug-induced SLE, photosensitivity
  • other: superinfection, candidiasis, vitamin B deficiency, hyperbilirubinemia, change of the color of tooth enamel in children

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Tetracycline overdose symptoms ?
If you overdose Tetracycline, seek immediate medical attention. Overdose symptoms include: nausea, vomiting, and diarrhea.

Which other medicines may affect Tetracycline?
Tetracycline may interact with the following groups of drugs:

  • indirect anticoagulants
  • some antibiotics
  • oral contraceptives
  • vitamin A
  • antacids
  • drugs containing Fe+
  • proteolytic enzyme

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Tetracycline, let your doctor know what other medicines, including OTC, you currently take.

How should I store Tetracycline?
Store the medicine at room temperature out of the reach of children.

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