Tinidazole

Generic Name (active ingredient): Tinidazole
Brand Name: Tindamax, Fasigyn

Tinidazole is antiprotozoal drug with antibacterial activity. Tinidazole is indicated for the treatment of protozoal infections caused by trichomoniasis, giardiasis, amebiasis, infections caused by anaerobic bacteria (pneumonia, empyema, lung abscess, ulcerative gingivitis, prevention of postoperative infectious complications caused by anaerobes), Helicobacter pylori eradication.

How does the medication work?
Tinidazole is a medication for the treatment of protozoal infections. It is highly effective against protozoa and obligate anaerobes: trichomonads, amoebas, giardias, causative microorganism of anaerobic infections. Action mechanism is associated with inhibiting synthesis and disturbing DNA chain. Tinidazole penetrates blood-brain barrier.

When Tinidazole is prescribed?
Tinidazole is used to treat:

  • Trichomoniasis
  • Giardiasis
  • Amebiasis (liver's form)
  • Infections caused by anaerobic bacteria: peritonitis, abscess, bacterial septicemia, postoperative wound infection, infection of skin and soft tissue, pneumonia, empyema, pulmonary abscess
  • Mixed aerobic-anaerobic infections (in combination with antibiotics)
  • Helicobacter pylori eradication (in combination with Bismuthi preparations and antibiotics)

Prophylaxis of post-operative anaerobic infections

What should I know before taking Tinidazole?
Do not use this medication if you are allergic to Tinidazoleor to any other medicines such as:
Metronidazole, Ornidazole and other azoles.

Do not take Tinidazole if any of the below conditions apply to you:

  • Organic diseases of central nervous system
  • Hemapoiesis disorders
  • Pregnancy
  • Breastfeeding (especially 1st trimester)
  • Children under 12 years of age

Before taking Tinidazole, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Liver diseases in anamnesis
  • Kidney diseases in anamnesis

If you are pregnant, plan to become pregnant, or breastfeed, you should take Tinidazole only under a strict control of your doctor. Tinidazole belongs to a pregnancy category C meaning that it may cause damage to the fetus.

How to take Tinidazole:
Tinidazole is available in the form of tablets which are taken orally swallowing whole. Do not crash, split or chew the tablets. Dosage of Tinidazole is prescribed individually by physician.

Take the entire amount of Tinidazole prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Tinidazole?
Tinidazole may cause the following side effects:

  • Dizziness
  • Ataxia
  • Peripheral neuropathy
  • Seizures
  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Metallic taste in the mouth
  • Headache
  • Coated tongue
  • Urine darkening
  • Allergic reactions (skin rash, itching, hives, angioedema)

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Tinidazole overdose symptoms?
If you overdose Tinidazole, seek immediate medical attention. Overdose symptoms include: vomiting, dizziness, loss of coordination, numbness and tingling, and seizures

Which other medicines may affect Tinidazole?
Tinidazole may interact with the following groups of drugs:

  • Alcohol. Tinidazole must not be used with tinidazole because of high risk of CNS disorders
  • Barbiturates
  • Blood thinners (warfarin)
  • Bile acid sequestrants
  • Lithium preparations
  • Anti-epileptic (phenytoin)
  • Antibiotics (oxytetracycline)

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Tinidazole, let your doctor know what other medicines, including OTC, you currently take.

How should I store Tinidazole?
You should store the medication at dry and protected from light place out of reach of children.

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