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Vancomycin

Generic Name (active ingredient): Vancomycin

Vancomycin is an antibacterial drug, which was derived from Amycolatopsis orientalis, the drug exerts bactericidal effects to a broad spectrum of microorganisms.

How does the medication work?
The preparation works by blocking the synthesis of the bacterial cell wall, however the drug does not work on the same fragment of the cell wall like penicillins and cephalosporins, thus the resistance to these antibiotics will not affect Vancomycin. The drug binds to the predecessor of the cellular wall thus causing the cell to lyze. The drug also is able to penetrate the cellular membrane of the bacteria and selectively inhibit RNA synthesis. The drug is active against a broad spectrum of gram-positive microorganisms. The preparation actively affects only bacterial cells that are in the process of replication. Most of the gram-negative bacteria are resistant to the drugs effect. The preparation does not express cross resistance to other antibiotics.

When Vancomycin is prescribed?
The drug is prescribed only in treatment of susceptible bacterial strains in the following disorders:

  • Sepsis
  • Endocarditis
  • Pneumonia
  • Lung abscess
  • Skin and joint infections
  • Meningitis
  • Pseudomembranous collitis
  • Clostridium difficile
  • Enterocollitis

What should I know before taking Vancomycin?
Do not use this medication if you are allergic to Vancomycin or to any other medicines such as:

  • Linezolid
  • Daptomycin

Do not take Vancomycin if any of the below conditions apply to you:

  • Hypersensitivity to any components of the preparation

Before taking Vancomycin, tell your health care provider about any other medicines you take or if you have any of the following disorders:

  • Renal failure
  • Hearing disorders

If you are pregnant, plan to become pregnant, or breastfeed, you should take Vancomycin only under a strict control of your doctor. Vancomycin belongs to a pregnancy category () meaning that...

How to take Vancomycin:
Vancomycin is available in the forms of intravenous injections.
The length of the treatment normally does not exceed 7 to 10 days.
Dosage of Vancomycin is prescribed individually by the physician in charge of the treatment.
Take the entire amount of Vancomycin prescribed by your doctor, even if you feel better before the end of the treatment. If you stop taking medication too early, symptoms may return.
If you missed the scheduled dose, take the medication as soon as you remember, but skip the dose if it is almost the time for the following dose. Do not take two doses at once.

What are the side effects of Vancomycin?
Vancomycin may cause the following side effects:

  • Postinfusive reactions
  • Anaphylactic reactions
  • Nephrotoxocity
  • Intersticial nephritis
  • Nausea
  • Pseudomembranous collitis
  • Ototoxicity
  • Vertigo
  • Ear ringing
  • Reversible neutropenia
  • Thrombocytopenia
  • Agranulocytosis
  • Local reactions
  • Allergic reactions
  • Toxic epidermal necrosis

If you experience any side effect that last long or becomes bothersome, please inform your doctor as dose adjustment or treatment discontinuation may be required.

Which are Vancomycin overdose symptoms?
If you overdose Vancomycin, seek immediate medical attention. Overdose symptoms include: Increase in the expression of side-effects. The treatment for the disorder is normally symptomatic, combined with hemofiltration, hemoperfusion.

Which other medicines may affect Vancomycin ?
Vancomycin may interact with the following groups of drugs:

  • Local anesthetics
  • Amynoglycoside antibiotics
  • Imidazole antibiotics
  • NSAID's
  • Immunosupressors
  • Diuretics
  • Other antibiotics
  • Epilepsy treatment
  • Antihistamines
  • Systemic anesthetics

For a complete list of possible interactions ask your doctor or pharmacist. Before taking Vancomycin, let your doctor know what other medicines, including OTC, you currently take.

How should I store Vancomycin?
The drug should be kept in a dry place, protected from direct sun rays, at temperatures not exceeding 8 ° C. Expiration time - 2 years. The drug should be kept away from children.